Preheat the oven to 425˚F. Lightly spray a baking sheet with cooking spray.
Place the salmon fillets on the baking sheet. Drizzle with sesame oil. Sprinkle with salt and pepper.
Bake in the preheated oven for 18-20 minutes, or until salmon easily flakes with a fork.
Meanwhile, in a small bowl, mix together the mayonnaise and the wasabi until fully combined.
Once salmon is done, top with wasabi mayo and sprinkle with sesame seeds.