Preheat the oven to 250℉.
In a large bowl, mix together the Chex cereals, pretzels, Cheerios, cashews and peanuts. Set aside.
In a separate bowl, mix together the butter, Worcestershire sauce, salt, onion powder and garlic powder.
Slowly pour the butter mixture over top the cereal mixture, mixing with a rubber spatula until the cereal mixture is coated.
Pour onto a 9x13 inch casserole dish and bake in the preheated oven for 1 hour, mixing every 15 minutes.
Place some paper towels on baking sheets and spread the hot Chex mixture on top. Allow to cool before storing in an airtight container.